Abstract
The efficiency of nanoparticle-based drug delivery systems to accumulate in targeted tumor sites is low owing primarily to the various biological mechanisms that promote premature clearance, such as renal filtration or the mononuclear phagocyte system (MPS). Such obstacles to enhanced tumor accumulation of nanomedicines remain formidable challenges to drug carrier design. It is thought that nanoparticles decorated with bioactive groups such as glycopolymers, compared to individual monovalent carbohydrate ligands, can assist in the enhanced delivery of payloads to tumors due to their multivalent effect. While glycopolymers are widely applied, limited attention has been dedicated to understanding how the presentation of glycopolymers on the surface of micelle may affect the biological activity. We utilized biodegradable and biocompatible polylactide–fructose block copolymers to investigate the effect of chain length of the hydrophilic fructose block on the biological activity. Three different fructose chain...
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