Abstract
Estimating the characteristic size of the tissue microstructure from a statistical analysis of the backscattered power spectrum could improve the diagnostic capability of medical ultrasound. Previously, size estimates were obtained for focused sources after compensating for source focusing, the frequency-dependent attenuation along the propagation path (total attenuation), and the frequency-dependent attenuation in the region of interest (local attenuation) given the attenuation values. In this study, the importance of the local attenuation on the scatterer size estimate was determined using computer simulations. The simulations used Gaussian impedance distributions with an effective radius of 25 μm randomly positioned in a homogeneous half-space (attenuation from 0.05 to 1 dB/cm-MHz) sonified by a spherically focused source (f/1 to f/4). The total attenuation and focusing were assumed known. The scatterer size was estimated assuming that the local attenuation was zero, the local attenuation was the mean value of the true attenuation over the frequency range used to obtain the estimates, and the local attenuation was 0.5 dB/cm-MHz. These three size estimates were then compared to estimates obtained using the true local attenuation value as well as estimates obtained when both focusing and local attenuation were not compensated.
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