Abstract
Background and Objective:Immune thrombocytopenic purpura (ITP) is a clinical syndrome in which a decreased number of circulating platelets (thrombocytopenia) manifests as a bleeding tendency, easy bruising (purpura) or extravasation of blood from capillaries into skin and mucous membranes (petechiae). The diagnosis of ITP can be made clinically on the basis of symptoms, we need to see if ITP can be confirmed in patients by quantification of residual RNA containing immature platelets (megakaryocytic mass) or immature platelets fraction (IPF) using automated hematology analyzers (Sysmex XE-2100).Methods:In order to check the efficacy of IPF% parameter of Sysmex XE-2100 a total of 231 patients of thrombocytopenia were included in this study. Complete blood count (CBC) was estimated. The data was statistically analyzed by SPSS version 17.Results:About 62 patients were diagnosed as ITP and 169 patients were diagnosed as non ITP on the basis of clinical history. The mean IPF % value of ITP patients was 16.39% and the IPF % value of Non ITP patients was ~7.69% respectively. There was no significant difference in IPF% values with respect to time between sampling and acquisition of complete blood count. The diagnostic sensitivity of IPF% as biomarker for ITP and non-ITP was 85.71% (95%CI: 84.04% to 85.96%) and 41.76% (95% CI: 39.87% to 43.65%).Conclusion:The mean IPF % value by Sysmex XE-2100 can be used to predict ITP.
Highlights
IntroductionLow/ decreased number of circulating mature platelets (thrombocytopenia) may lead to excessive bleeding, easy bruising (purpura), or extravasations of blood from capillaries into skin and mucous membranes (petechiae).[1] This condition was previously termed as idiopathic thrombocytopenia purpura, it is well known that in most of the cases cause is not idiopathic but autoimmune with antibodies against platelets being detected in patients and associated with high megakaryocytic mass in bone marrow
The platelets are the key player in controlling bleeding problems
Low/ decreased number of circulating mature platelets may lead to excessive bleeding, easy bruising, or extravasations of blood from capillaries into skin and mucous membranes.[1]. This condition was previously termed as idiopathic thrombocytopenia purpura, it is well known that in most of the cases cause is not idiopathic but autoimmune with antibodies against platelets being detected in patients and associated with high megakaryocytic mass in bone marrow
Summary
Low/ decreased number of circulating mature platelets (thrombocytopenia) may lead to excessive bleeding, easy bruising (purpura), or extravasations of blood from capillaries into skin and mucous membranes (petechiae).[1] This condition was previously termed as idiopathic thrombocytopenia purpura, it is well known that in most of the cases cause is not idiopathic but autoimmune with antibodies against platelets being detected in patients and associated with high megakaryocytic mass in bone marrow. Immune thrombocytopenic purpura (ITP) is a clinical syndrome in which a decreased number of circulating platelets (thrombocytopenia) manifests as a bleeding tendency, easy bruising (purpura) or extravasation of blood from capillaries into skin and mucous membranes (petechiae). Conclusion: The mean IPF % value by Sysmex XE-2100 can be used to predict ITP
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