Abstract
Importance of Detection of Isoniazid and Rifampicin Mono Drug Resistance and Determining Rate of MDR-TB in Smear Positive Sputum Samples from a Tertiary Care Hospital of West U.P. India
Highlights
Tuberculosis remains as one of the most common infectious disease in developing countries still in 21st century[1]
We found there is a high rate of INH mono resistance which was not being detected till from this area and we found, there is unrelated risk of isoniazid and rifampicin mono-resistance so, inference of MDR based on RIF mono- resistance is an inaccurate strategy to manage patients and drug sensitivity should be performed for both first line drug before stating MDR
Among all M. tuberculosis isolates tested for drug susceptibility, 10.9% were resistant to one anti – TB drug and 6.7% were resistant to both isoniazid and rifampicin
Summary
Tuberculosis remains as one of the most common infectious disease in developing countries still in 21st century[1]. Tuberculosis is an important international health problem and this issue has become even more prominent as a result of increasing number of drug resistant strains[2]. First line drugs including rifampicin, isoniazid, ethambutol, pyrazinamide and streptomycin are the preferred choice for TB control. MDR – TB strains has become a serious public health problem in developing countries and has consistently been contributing to increased annual TB incidence rates[3]. Resistant to at least isoniazid and rifampicin is of great concern because it requires the use of second line drugs that are difficult to procure and are much more toxic and expensive than the first line regime. Among all M. tuberculosis isolates tested for drug susceptibility, 10.9% were resistant to one anti – TB drug and 6.7% were resistant to both isoniazid and rifampicin. An estimated 3.6% of new cases and 20.2% of previously treated cases are due to MDR – TB4
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