Abstract
LS174T human colon cancer cells exhibited typical epithelial polarity and formed glandular structures with microvilli, tight junctions, desmosomes and basal laminae arranged in order as in normal intestinal epithelial cells when combined with fetal rat mesenchymes or collagen gels in organ culture. Quantitative analysis showed that the number of desmosomes per unit area was always much greater in subluminal areas of lumen-forming LS174T cells than in other areas irrespective of the culture period or culture method, and this was also the case with rat intestinal epithelial cells in normal development. In contrast, no such clear relationship could be found between the glandular organization of LS174T cells and formation of other ultrastructural components examined (microvilli, tight junctions and basal laminae). These results suggest that desmosome formation plays important role in the glandular organization of intestinal epithelial cells.
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