Importance of Cell-Mediated Immunity in Marek's Disease and Other Viral Tumor Diseases

Abstract

Cell-mediated immune (CMI) responses to viral tumor diseases are often used as examples of the importance of antiviral and antitumor immunity in chickens. Especially, reticuloendotheliosis virus (REV) and Marek's disease herpesvirus (MDV) are used as models to study the development of cytotoxic T-lymphocytes against viral and tumor antigens and activation of natural killer (NK) cells. Major histocompatibility complex Class I-restricted, antiviral cytotoxic T-lymphocytes expressing CD4–/CD8+ markers are induced after infection with REV. Thus far, this is the only example of Class I-restricted cytotoxic T-lymphocytes in chickens. Antiviral cytotoxic T-lymphocytes may be induced by infection with MDV or by vaccination, but conclusive evidence has not yet been provided. Antitumor responses have not been demonstrated against REV-induced tumors. Although Marek's disease is often used as an example for the importance of antitumor immunity, there is a lack of convincing data demonstrating antitumor immunity mediated by cytotoxic T-lymphocytes. Activation of NK cells by MDV infection or vaccination is probably an important part of CMI responses against Marek's disease viral antigens but not against tumor antigens.