Abstract
Green tea is commonly used as a beverage worldwide, especially in China, Japan, Morocco, and Saudi Arabia. Green tea and its constituents have been considered very effective in the prevention and treatment of various diseases. It contains a variety of catechins, which show a pivotal role in the modulation of biological activities and also act as chemopreventive agents. Earlier studies have confirmed that green tea and its chief constituent epigallocatechin gallate (EGCG) have a potential role in the management of cancer through the modulation of cell signaling pathways. In this review, we focused on the beneficial effects of green tea and its constituents in the cancer prevention and treatment and its impact on modulation of molecular pathways.
Highlights
Natural products, mainly plants and their constituents, have been used in the diseases cure from the ancient time and its role in the health management is very popular in India, China, and other parts of the world
An important study revealed that epigallocatechin gallate (EGCG), a chief constituent of green tea, significantly reduced tumor volume in xenograft mouse model breast cancer cells [10] and a study summarized the role of the green tea constituents EGCG in chemoprevention [11]
Experiment was carried out to evaluate the effects of EGCG (10–100 μg/mL) treatment on growth and invasion in a breast carcinoma cell line resistant to tamoxifen (MCF-7Tam) and parental MCF-7 and the results revealed that dose-dependent downregulation of epidermal growth factor receptor (EGFR) mRNA expression and protein level occurred after 50 μg/mL EGCG treatments of MCF-7Tam cells [56]
Summary
Mainly plants and their constituents, have been used in the diseases cure from the ancient time and its role in the health management is very popular in India, China, and other parts of the world. The anticancer effects of (−)-epigallocatechin gallate have been reported via modulation of signaling pathways and play a role in the downregulation of proteins expression involved in the invasiveness of cancer cells [8]. Another finding has shown that EGCG inhibited growth of the mouse viral mammary epithelial carcinogenesis model; induced apoptosis and finding suggest the clinical relevance of EGCG as a chemopreventive agent [9]. Epigallocatechin-3-gallate Figure 1: Active constituents of green tea
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