Implications for Nurses and the Supportive Care Needs for Children Undergoing Reduced Intensity Conditioning (RIC) Allogeneic Stem Cell Transplantation (RIC-AlloSCT)

Abstract

Allogeneic hematopoietic stem transplant (AlloSCT) is a curative option for many children with malignant and non-malignant disorders. However, myeloablative AlloSCTs are associated with 20–40% non-relapse related mortality (NRM) in first 100 days post AlloSCT (Satwani/Cairo et al, BBMT 2005, PBC 2007). The morbidity and mortality associated with AlloSCT often result in an increase in length and complexity of nursing care. However, RIC-SCT may potentially reduce toxicities and lead to a reduction in supportive care needs associated with an increase in nursing care; including reduction of blood products, antibiotics, TPN, and narcotics.