Implication of healthy lifestyles and the taking of Fortasyn Connect© in the cognitive impairment evolution

Abstract

AbstractBackgroundThere is increasing evidence that beyond modifiable risk factors there are modifiable factors associated with Alzheimer's disease, including those related to cardiovascular risk ‐ high blood pressure, hypercholesterolemia, diabetes, smoking and overweight. And with a diet lifestyle, physical exercise and cognitive and social activity. Based on this premise, we analyze on a series of patients treated with Fortasyn connect (Souvenaid®) their “healthy life” habits.MethodOn 39 patients with mild cognitive impairment or mild Alzheimer's disease in treatment with Souvenaid®, life habits questionnaires were completed in daily and leisure activities, in social and food participation.ResultWe studied 39 subjects around the age of 81.1 years (± 4.5), in treatment with Souvenaid ® (53.8% associated with IAch and 10.3% with memantine). Compliance with Souvenaid ® treatment was 79.5% (due to intolerance dropped 7.7%). The mean treatment follow‐up of patients who finished the study was 12.9 months (± 8.0). The adherence to the Mediterranean diet was moderate. 37.8% of the subjects maintained or improved the MMSE score at the time of follow‐up. The loss of the monthly MMSE score tended to be greater in the elderly (p = 0.082) and was significantly lower in those who regularly drove (p = 0.009), read (p = 0.036) or engaged in light physical activity (p = 0.018). In the multivariate study, driving and light physical activity was associated with a lower monthly loss of MMSE.ConclusionThe study of healthy lifestyles could help elucidate the best combination of pharmacological and non‐pharmacological treatments, in order to develop a "precision medicine" approach and an individual and multimodal strategies, in order to prevent, diagnose and develop therapies more precise and effective against AD.