Abstract
Spondyloarthritis is a chronic inflammatory disease, whose pathogeny involves microbial agents, genetic factors and the gut, leading to inflammation in several target tissues. The Th7 pathway corresponds to polarization of CD4 naive cells towards Thi 7 cells (produ- cing predominantly IL-17 and IL-22) under the influence of IL-23, completing the IL-23IThJ 7 axis. This pathway is activated and involved at several levels in spondyloarth- ritis : microbial contact (microbiota and dysbiosis), HLA-B27 (misfolding) and gut inflammation. IL-23 receptor expressing cells were found in enthuses of animal model, and migrating from gut to blood, bone marrow and joint in humans. The involvement of this pathway allows insight into targeted therapies against IL-I 7 or IL-23 in spondyloarthritis.
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