Implementation of Wavelet-Transform-Based Algorithms in an FPGA for Heart Rate and RT Interval Automatic Measurements in Real Time: Application in a Long-Term Ambulatory Electrocardiogram Monitor.

Abstract

Cardiovascular diseases are currently the leading cause of death worldwide. Thus, there is a need for non-invasive ambulatory (Holter) ECG monitors with automatic measurements of ECG intervals to evaluate electrocardiographic abnormalities of patients with cardiac diseases. This work presents the implementation of algorithms in an FPGA for beat-to-beat heart rate and RT interval measurements based on the continuous wavelet transform (CWT) with splines for a prototype of an ambulatory ECG monitor of three leads. The prototype's main elements are an analog-digital converter ADS1294, an FPGA of Xilinx XC7A35T-ICPG236C of the Artix-7 family of low consumption, immersed in a low-scale Cmod-A7 development card integration, an LCD display and a micro-SD memory of 16 Gb. A main state machine initializes and manages the simultaneous acquisition of three leads from the ADS1294 and filters the signals using a FIR filter. The algorithm based on the CWT with splines detects the QRS complex (R or S wave) and then the T-wave end using a search window. Finally, the heart rate (60/RR interval) and the RT interval (from R peak to T-wave end) are calculated for analysis of its dynamics. The micro-SD memory stores the three leads and the RR and RT intervals, and an LCD screen displays the beat-to-beat values of heart rate, RT interval and the electrode connection. The algorithm implemented on the FPGA achieved satisfactory results in detecting different morphologies of QRS complexes and T wave in real time for the analysis of heart rate and RT interval dynamics.