Abstract
A six-dimensional molecular-replacement procedure has been implemented using Perl scripts and theCCP4 version of the translation function of the molecular-replacement programAMoRe. These tools have allowed the structure determination of CTLA-4 monomer from NMR-derived coordinates, and of a potential complex of MurD with a substrate. In both cases other molecular-replacement programs,X-PLORandAMoRe, when used in a conventional manner, either failed or did not yield an obvious solution.
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