Implementación universal del «consecutive combined test» en el área sur de Sevilla (Hospital Universitario Valme)

Abstract

Universal application should be an aim in chromosomal abnormality screening, in addition to achieving adequate sensitivity and an acceptable false positive rate of the screening method applied. Objectives We aimed to implement universal chromosomal abnormality screening (coverage greater than 90% of pregnancies) in the southern area of Seville and to maintain the rate of diagnosis at 80% and the false-positive rate at 5%. Method Between July 2005 and September 2008, chromosomal abnormality screening through the consecutive combined test was offered to pregnant women in the southern area of Seville. The Double Test was used in women accessing screening later than 13 weeks of pregnancy. Results Of 12,478 pregnant women, chromosomal abnormality screening was offered to 95.1%. The consecutive combined test was performed in 86.86% of the pregnancies and screening was rejected by 6.32% of patients. Thirty-five chromosomal abnormalities were detected (a prevalence of 0.28%), of which 31 (88.5%) were diagnosed prenatally. The false-positive rate was 4.31%. Conclusions Universal application should be an objective of chromosomal abnormality screening, in addition to achieving adequate sensitivity and an acceptable false-positive rate in the screening method applied.