Abstract

ABSTRACT Decades of research and improving technology have taken in vitro fertilization techniques to a highly sophisticated level. Attention in the later twentieth century was increasingly paid to the endocrine stimulation of follicle growth and oocyte maturation. Hormonal stimulation became more complex. Methods for ovarian hyperstimulation became complex. GnRH agonists and antagonists came into play to provide a better control over FSH and LH concentrations during follicular and luteal phases of stimulated cycles including the correction of premature LH surges. A lot of stress is being paid nowadays on natural remedies to replace the high tech treatment modalities and so also evolved the so called natural cycle in vitro fertilization, the drug free or minimal drug fertility treatment. There are opinions worldwide of experts that the methods that are currently being used for ovulation and to stimulate growth of the follicle in infertile women are too expensive in addition to being extreme measures. Not only are they costly but the effect on the human body has given rise for the need for a more nature-friendly method. Alternative approaches are therefore being sought including minimal stimulation IVF, natural cycle IVF and maturing human oocytes in vitro to prepare them for fertilization in vitro. Each of these approaches avoids the use of large doses of human menopausal gonadotrophin (HMG) that have become essential for routine IVF. This article reviews the available literature on these methods and also their fallacies, if any.

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