Abstract
The University of Tokyo has been involved in research and development of the artificial heart since 1959. This paper is a brief review of 40 years of total artificial heart research in the University of Tokyo. Many types of artificial heart and various kinds of materials, blood pumps, valves, drive units, control methods, and pathophysiology have been investigated in our original fashion. The longest survival was 532 days for a goat with a total artificial heart (TAH) placed on the chest wall. These results made us take a step toward the development of an implantable TAH. Two kinds of implantable TAH are now being developed: FTPTAH (flow-transformed pulsatile total artificial heart) and UPTAH (undulation pump total artificial heart). Recently, a goat survived for 31 days with an UPTAH.
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