Abstract
During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices. Among them, the combination of optogenetics and electrophysiology provides an opportunity for facilitating optogenetic approaches. In this study, a novel design of an optrode array was proposed for realizing optical modulation and electrophysiological recording. A 4 × 4 optrode array and five-channel recording electrodes were assembled as a disposable part, while a reusable part comprised an LED (light-emitting diode) source and a power line. After the characterization of the intensity of the light delivered at the fiber tips, in vivo animal experiment was performed with transgenic mice expressing channelrhodopsin, showing the effectiveness of optical activation and neural recording.
Highlights
For more than a decade, optogenetics has been widely employed to investigate a variety of neural mechanisms in neuroscience studies [1,2,3,4,5,6,7,8,9]
As the optogenetic technique became popular, the need for simultaneous neural recording has grown in order to confirm optical neuromodulation
An integrated device that can simultaneously deliver light stimuli to activate or inhibit specific neuronal cells and record the neural response activities has been highly demanded [9,11,12,13,14,15,16,17,18]. As this micro-electro-mechanical systems (MEMS) technology advances, optical stimulation and recording system configuration can be fabricated on a microscale [19,20,21,22,23,24,25]
Summary
For more than a decade, optogenetics has been widely employed to investigate a variety of neural mechanisms in neuroscience studies [1,2,3,4,5,6,7,8,9]. An integrated device that can simultaneously deliver light stimuli to activate or inhibit specific neuronal cells and record the neural response activities has been highly demanded [9,11,12,13,14,15,16,17,18]. As this micro-electro-mechanical systems (MEMS) technology advances, optical stimulation and recording system configuration can be fabricated on a microscale [19,20,21,22,23,24,25]. A MEMS-based optrode is considered to be one of the promising optogenetic platforms
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