Abstract
Osteosynthesis materials or artificial joint replacement make part of clinical routine. In case of complaints mostly mechanical causes or infections are found. Metals like nickel, chromium and cobalt or bone cement components like acrylates and gentamicine may however potentially cause intolerance reactions to implants. Correspondingly, eczema, delayed wound/bone healing, recurrent effusion, pain or implant loosening have been described as manifestation of implant allergy. In contrast to the high incidence of cutaneous metal allergy, allergies associated with implants are rare. Diagnosis of metal implant allergy is based on excluding differential diagnoses – in particular infection – and on a combined approach of allergological diagnostics by patch test and histopathology of periimplant tissue. Risk factors for allergic sensitization to implants or triggering periimplant allergic reactions in the case of preexisting cutaneous metal allergy are unknown. Despite the risk of developing complications being unclear, titanium-based osteosynthesis materials are recommended for metal-allergic patients and the use of metal-metal couplings in arthroplasty is rather not recommended for such patients. If a regular, potentially applicable CoCr-polyethylene articulation is preferred, the patient has to be well informed and has to give his written consent.
Highlights
Osteosynthesis materials and artificial joint replacements – especially artificial hip and knee joints – are implanted more than 300,000 times per year in Germany alone
Diagnosis of metal implant allergy should always be made in consideration of clinical findings, results of patch testing and periimplant histopathology
This means that only in the synopsis of several diagnostic steps and findings the symptoms can be interpreted as allergic reaction and the patch test result is only partially applicable to periimplant tissue
Summary
In case of complaints mostly mechanical causes or infections are found. Chromium and cobalt or bone cement components like acrylates and gentamicine may potentially cause intolerance reactions to implants. In contrast to the high incidence of cutaneous metal allergy, allergies associated with implants are rare. Diagnosis of metal implant allergy is based on excluding differential diagnoses – in particular infection – and on a combined approach of allergological diagnostics by patch test and histopathology of periimplant tissue. Risk factors for allergic sensitization to implants or triggering periimplant allergic reactions in the case of preexisting cutaneous metal allergy are unknown. Despite the risk of developing complications being unclear, titanium-based osteosynthesis materials are recommended for metal-allergic patients and the use of metal-metal couplings in arthroplasty is rather not recommended for such patients. Potentially applicable CoCr-polyethylene articulation is preferred, the patient has to be well informed and has to give his written consent
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