Abstract
Positron Emission Tomography (PET) has become a standard clinical practice in the diagnostic or prognostic imaging of cancer mainly due to the great success of [18F]FDG (2-deoxy-2-18F-fluoro-D-glucose) for non-invasive detection of glucose uptake in tumors.[1] Currently 11C and 18F are the most commonly used PET nuclides for the development of PET imaging probes. However, the short half-lives of these two radioisotopes (11C: t1/2 = 20.3 m; 18F: t1/2 = 109 m) limit their applications to biomolecules with relatively fast in vivo biodistribution kinetics and the chemical procedures to incorporated these isotopes must be carried out in the proximity of a biomedical cyclotron. Among the non-standard PET nuclides, 64Cu (t1/2 = 12.7 h; β+: 0.653 MeV, 17.4%) has drawn considerable interest in PET research due to its low positron range, commercial availability, and reasonably long decay half life. Such characteristics could enable a variety of imaging applications involving peptides, antibodies/fragments, and nanoparticles.[2, 3]
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