Abstract
Publisher Summary The dual purpose of this chapter is (1) to review the case for apparent age-dependent changes in the availability of hormones which regulate in vivo the activity of glucokinase and tyrosine aminotransferase in rat liver, and (2) to implicate a possible age-dependent role for pituitary regulation of endocrine cell function. The time course of enzyme adaptations probably represents a general biochemical manifestation of modifications in the availability of hormones throughout life span. Importance of both insulin and adrenal hormones, whose production is impaired by aging, is evident for physiological regulation of glucokinase and tyrosine aminotransferase activities. The inability to modify age dependence of the enzyme adaptation by replacement of the cell population in vivo could be interpreted by means of either or both of two possible mechanisms: (1) modified liver enzyme regulation in aging animals is the consequence of genetic alterations that are copied during the regenerative process following partial hepatectomy; and (2) the age-dependent modifications reflect changes which are extrahepatic in origin.
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