Abstract
High-affinity Ca2+-transport ATPases are key components in the machinery of cytosolic Ca2+ regulation. We have found that the Ca2+-dependence of plasma membrane Ca2+-ATPase (PMCA) activity is constant between pCa values of 6.5 and 4.5 in membranes from Alzheimer's disease (AD) affected-brain whereas in normal brain the activity increases from pCa 6.5 to 5.5 and then decreases from 5.5 to 4.5. However, the Ca2+-dependencies of sarco(endo)plasmic- (SERCA) and secretory pathway- (SPCA) Ca2+-ATPases activity are similar in AD and normal brains.
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