Abstract
In skeletal muscle, insulin-induced glucose transport is known to start from the translocation of glucose transporter (GLUT) 4 from intracellular pool to plasma membrane. KK-Ay mouse, a genetic animal model of type 2 diabetes, develops moderate degrees of obesity and diabetes that are especially apparent in animals of more than 11 week old. Defect in insulin-induced GLUT4 translocation may also be involved in the geneses of type 2 diabetes mellitus. We examined the alteration of insulin-induced GLUT4 translocation in the skeletal muscle. After isolation of low density microsomal membrane and plasma membrane in skeletal muscle, insulin-induced translocation of GLUT4 in KK-Ay mouse were examined by Western blotting method. The insulin-induced translocation of GLUT4 from low density microsomal membranes to plasma membrane was significantly reduced in skeletal muscle of KK-Ay mice when compared with that in the ddY mice. These results support a view that the reduction of insulin-induced GLUT4 translocation in skeletal muscle may be involved in the deferioration of insulin sensitivity in diabetic KK-Ay mice.
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