Abstract

Bilateral administrations of crystalline 6-hydroxydopamine to the ventral anterior striatum of rats reliably impaired the performance of avoidance responses. The 6-OHDA treatments depleted the forebrain of dopamine but did not reliably alter forebrain levels of norepinephrine. A significant correlation was found between the extent of the depletion of forebrain dopamine and the magnitude of the avoidance deficit. These results support the hypothesis that dopaminergic components of the striatum may be involved in avoidance behavior.

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