Abstract
Rationale: Arginine (ARG) is the only amino acid that generates significant amounts of nitric oxide (NO), a powerful regulator of circulation, and a neurotransmitter. Insulin-stimulated NO production is impaired in diabetic conditions in the presence of insulin resistance. A novel approach of metabolic flux analyses was used to identify specific perturbations in whole-body ARG metabolism in type 2 diabetes (T2D).
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