Abstract
Previous study has demonstrated that the lack of μ-opioid receptor decreased LTP in the dentate gyrus of the hippocampus, suggesting the possibility that the lack of μ-opioid receptor may accompany a change in learning and memory. However, no behavioral study has been undertaken to correlate LTP deficits with spatial memory impairment in μ-opioid receptor knockout mice. Therefore, the present study investigated the hypothesis that μ-opioid receptors contribute to learning and memory by using the Morris water maze, and comparing responses in wild type and μ-opioid receptor gene knockout mice. Our results indicated that μ-opioid receptor knockout mice showed a significant spatial memory impairment compared to wild type in the Morris water maze. This result suggests that the expression of μ-opioid receptor plays an important role in spatial learning and memory examined by Morris water maze.
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