Abstract
The food intake rejection response to quinine adulterated diet was examined in chronically theophyllinized rats in comparison with saline injected controls. Food intake of normal rats was suppressed by quinine in proportion to concentration from 0% to 1.2%. The suppressive effect of quinine as a function of time was most prominent on the 1st day of adulteration. After chronic theophylline treatment, the rats became less reactive to taste than the controls when exposed to diet adulterated with 0.1% or 0.2% quinine, a moderate concentration for feeding suppression. This change in food intake rejection response was considered to be due to impairment of taste discrimination against quinine caused by the chronic theophylline administration.
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