Abstract
PKCγ is highly expressed in Purkinje cells (PCs) but not in other types of neurons in the cerebellum. The expression of PKCγ changes markedly during cerebellar development, being very low at birth and reaching a peak around the third postnatal week. This temporal pattern of PKCγ expression coincides with the developmental transition from multiple to single climbing fiber innervation onto each PC. In adult mutant mice deficient in PKCγ, we found that 41% of PCs are still innervated by multiple climbing fibers, while other aspects of the cerebellum including the morphology and excitatory synaptic transmission of PCs appear normal. Thus, elimination of multiple climbing fiber innervation appears to be specifically impaired in the mutant cerebellum. We suggest that the developmental role of PKCγ may be to act as a downstream element in the signal cascade necessary for the elimination of surplus climbing fiber synapses.
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