Abstract
A recent study demonstrated a significant correlation between bronchial biopsy airway remodelling with quantitative computed tomography looking at bronchial wall thickness. To identify clinical associations with bronchial wall thickness in moderate-to-severe asthma. 92 respiratory physician diagnosed GINA-defined moderate-to-severe asthma patients were included in this retrospective cohort study. Blinded to all clinical data, two senior thoracic radiologists independently measured airway lumen and total airway area at four different bronchopulmonary segments using high resolution CT imaging. We calculated adjusted odds ratios (aORs) in regard to the association of bronchial wall thickness with spirometry, oscillometry, exacerbations and nasal polyps. The pooled analysis for all four bronchopulmonary segments showed that AX≥1.0kPa/L, R5-R20 ratio ≥25%, ≥2 exac/yr and nasal polyposis exhibited aOR (95%CI) of 3.54 (1.22,10.32); 2.89 (1.03,8.05); 4.17 (1.25,13.90); and 9.85 (2.33,41.74) respectively in their association with wall area thickness ≥50%. These translated into a respective 72%, 65%, 76% and 90% increased likelihood for wall area ≥50%. Bronchial wall thickness is associated with peripheral airways resistance and reactance, severe exacerbations and nasal polyposis in persistent asthma.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of Allergy and Clinical Immunology: In Practice
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
