Abstract
Abstract— L5178Y‐R (LY‐R) and L5178Y‐S (LY‐S) cells differ in sensitivity to UVC radiation (D0: 2.8 and 9.0 J/m2respectively, for cells exposed in Fischer's medium). We used these cells and a DNA unwinding technique in conjunction with 1‐β‐D‐arabinosyl cytosine to determine DNA strand breaks accumulating as a result of enzymatic incision during DNA repair. Following UVC exposure DNA strand break accumulation was observed in LY‐S cells but not in LY‐R cells. The repair defect in LY‐R cells is accompanied by a delayed recovery of [3H]thymidine incorporation.
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