Abstract
Logopenic variant primary progressive aphasia (lvPPA) is the least well defined of the major primary progressive aphasia (PPA) syndromes. We assessed phoneme discrimination in patients with PPA (semantic, nonfluent/agrammatic, and logopenic variants) and typical Alzheimer’s disease, relative to healthy age‐matched participants. The lvPPA group performed significantly worse than all other groups apart from tAD, after adjusting for auditory verbal working memory. In the combined PPA cohort, voxel‐based morphometry correlated phonemic discrimination score with grey matter in left angular gyrus. Our findings suggest that impaired phonemic discrimination may help differentiate lvPPA from other PPA subtypes, with important diagnostic and management implications.
Highlights
The logopenic variant of primary progressive aphasia is the least well defined of the three major primary progressive aphasia (PPA) syndromes.[1]
Based on previous work,[2,6,9] we predicted that phonemic discrimination would be most markedly affected in logopenic variant of primary progressive aphasia (lvPPA), with a regional grey matter correlate in left temporo-parietal cortex
Our findings demonstrate that patients with lvPPA perform worse on phonemic discrimination than both healthy older individuals and patients with other major variants of PPA
Summary
The logopenic variant of primary progressive aphasia (lvPPA) is the least well defined of the three major primary progressive aphasia (PPA) syndromes.[1]. Based on previous work,[2,6,9] we predicted that phonemic discrimination would be most markedly affected in lvPPA, with a regional grey matter correlate in left temporo-parietal cortex
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