Abstract
Lymphocyte transformation was measured to assess immunologic competence in acute lymphatic leukemia. The in vitro lymphocyte transformation in response to pokeweed mitogen was studied in 3 groups of children: 1. 11 normal controls, 2. 9 leukemic children in remission who had not received intensive therapy, and 3. 9 leukemic children who had completed intensive x-ray and chemotherapy. The responses of the first and second groups were similar. In the third group, lymphocyte transformation was impaired one month after all therapy had been discontinued in 8/9 patients. Six of these 9 patients were studied 2 months after cessation of therapy and the lymphocyte transformation was still impaired (6/6). Serial monthly studies in 3 patients demonstrated that this impaired transformation persisted for 3 months or longer. Intensive forms of chemotherapy-radiotherapy used to treat acute lymphatic leukemia can cause prolonged impairment of lymphocyte transformation.
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