Abstract
BackgroundIt is well known that lipids abnormally accumulate in the alveoli during idiopathic pulmonary alveolar proteinosis (PAP). It is unclear, however, whether lipids also abnormally accumulate in serum. This study investigated the serum lipid panels in idiopathic PAP patients and explored the relationships between serum levels and the severity of idiopathic PAP.Methods and ResultsClinical data including the level of serum lipids were evaluated in 33 non-diabetic idiopathic PAP patients and 157 healthy volunteers. Serum levels of triglyceride were higher in PAP patients than in healthy subjects (median: 192.00 mg/dl (P25: 104.36, P75: 219.00) vs 119.56 mg/dl (P25: 78.81, P75: 193.03), P < 0.05), while high-density lipoprotein cholesterol (HDL-C) levels were lower in patients than in the control group (42.50 ± 10.30 vs 51.34 ± 12.06 mg/dl, P < 0.01). Forced expiratory volume in one second and forced vital capacity in hypertriglyceridemia patients were lower than those in patients with normal triglyceride. Serum LDL-C and HDL-C ratio correlated negatively with PaO2 (r = -0.403, P < 0.05) and positively with lactate dehydrogenase (r = 0.381, P < 0.05).ConclusionsPAP associates with high triglyceride and low HDL levels in the serum, and these lipids provide potential intervention strategy for treatment.
Highlights
Pulmonary alveolar proteinosis (PAP) is a rare lung disease in which the alveolar spaces are filled with lipoproteinaceous material [1,2]
The mean systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting serum glucose levels were all within normal ranges, and there was no significant difference between the two groups (p = NS)
119.56 ± 32.04 mg/dl respectively, p = 0.03) were higher in pulmonary alveolar proteinosis (PAP) patients than healthy subjects, while high-density lipoprotein cholesterol (HDL-C) levels were lower in patients than those in controls (42.56 ± 10.30 mg/dl vs 51.34 ± 12.06 mg/dl, p < 0.001)
Summary
Pulmonary alveolar proteinosis (PAP) is a rare lung disease in which the alveolar spaces are filled with lipoproteinaceous material [1,2]. More than 90% of PAP patients are idiopathic [2]. Most patients with PAP are symptomatic with progressive exertional dyspnea of insidious onset and cough, and are hypoxemic in room air. A primary complication of PAP is that it predisposes patients to pulmonary infections. The primary treatment strategy for idiopathic PAP is whole lung lavage. It is well known that lipids abnormally accumulate in the alveoli during idiopathic pulmonary alveolar proteinosis (PAP). It is unclear, whether lipids abnormally accumulate in serum.
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