Impaired host resistance against local JMV Marek's disease tumors after thymectomy and after bursectomy.

Abstract

It has been well established that the immune system of the chicken displays a dichotomy of responsiveness. Thymectomy in the newly-hatched period, combined with sublethal irradiation, has been demonstrated to significantly impair cell-mediated immunological functions (Cooper et al., 1966). Surgical bursectomy in the newly-hatched period impairs antibody-forming capacity (Glick et al., 1956). Treatment with high doses of cyclophosphamide during the first days of life results in a more profound, selective deficiency of the bursa-dependent, antibody-forming system in month-old or older animals (Lerman and Weidanz, 1970; Linna et al., 1972). The delineation of immunological responsiveness in the chicken can be used to study the influences of cell-mediated immunity, and of the antibody-forming system on tumor development.KeywordsTumor BearerCyclophosphamide TreatmentFisher Exact Probability TestSublethal IrradiationVirus Tumor InductionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.