Abstract
Background There is a graded inverse relationship from early stages of chronic kidney disease (CKD) (GFR<75ml/min/ 1.73m2) with increased cardiovascular risk that is driven by high rates of heart failure and sudden cardiac death. Abnormal left ventricular (LV) deformation is an independent predictor of poor prognosis in endstage CKD and is thought to reflect the extensive interstitial fibrosis and myocyte disarray documented on LV biopsy in uremic cardiomyopathy (UC). There remains a paucity of data relating to the onset of UC in early stage CKD.
Highlights
There is a graded inverse relationship from early stages of chronic kidney disease (CKD) (GFR
Abnormal left ventricular (LV) deformation is an independent predictor of poor prognosis in endstage CKD and is thought to reflect the extensive interstitial fibrosis and myocyte disarray documented on LV biopsy in uremic cardiomyopathy (UC)
Global longitudinal LV strain (-14.2% +/- 1.7 vs. -15.9% +/- 2.3, p
Summary
There is a graded inverse relationship from early stages of chronic kidney disease (CKD) (GFR
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