Abstract
BackgroundHeart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia. The purpose of this pilot study is to evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals.MethodsIdiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-h ambulatory ECG was performed.ResultsOverall, 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6 ± 8.8, disease duration: 5.0 ± 4.7). Mean SCOPA-AUT score was 10.1 ± 7.3. Patients were on Hoehn & Yahr stage 1–2 and mean Levodopa Equivalent Dose (LED) was 311 ± 239.9. Mean of the 5-min standard deviation (SD) of R-R intervals distribution (SDNN) for all 5 min segments of the entire recording (ISDNN) was significantly lower in patients compared to controls. ISDNN was significantly different between Parkinson’s disease patients and healthy controls.ConclusionsIn our population characterized by mild to moderate disease severity, time-domain assessment of HRV seemed to be a potential tool to characterize cardiovascular dysautonomia. Decrease of ISDNN in PD may reflect an autonomic derangement extending all day and night long.
Highlights
Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia
Overall, eighteen PD patients (9 males) with a mean disease duration of 50 ± 4.7 years were enrolled in this study
No significant difference of age at HRV evaluation was observed between PD patients, and controls (p = 0.8)
Summary
Heart rate variability (HRV) decreases in Parkinson’s disease (PD) and it can be considered a marker for cardiovascular dysautonomia. The purpose of this pilot study is to evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals. Heart rate variability (HRV) is decreased in Parkinson’s disease (PD) and it could occur early [1] in the course of the disease. HRV might be evaluated by a short term (usually 5 min) ECG recording obtained under controlled standardized conditions and long term analysis [3]. The main aim of our study was to evaluate whether a difference between PD patients without comorbidities impairing long term time-domain HRV and healthy. A time-domain assessment of HRV was performed using a long term recording
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