Impaired biological rhythm in men with methamphetamine use disorder: the relationship with sleep quality and depression

Abstract

ABSTRACT Background This study, it was aimed to evaluate the biological rhythms of those with methamphetamine use disorder and to examine the relationship of biological rhythm with depression and sleep quality. Methods A total of 121 people (61 with methamphetamine use disorder, 60 healthy controls) participated in the study. Sociodemographic data forms, Pittsburgh Sleep Quality Index, Biological Rhythms Interview of Assessment and Hamilton Depression Rating Scale (HAM-D) were administered for all patients and the healthy control group. Results Biological rhythm total scores of the patient group were higher than the control group (p < .001). When the correlation analyses were examined, r = 0.864 positive (p < .001) correlation was found between biological rhythm total scores and HAM-D; and r = 0.713 positive (p < .001) correlation between Pittsburgh total scores and biological rhythm total scores. According to the regression analysis, the total change in the biological rhythm total score level was 75.8, explained by the HAM-D total scores and Pittsburgh total scores (R2 = 0.758). Conclusions Chronotherapies can be considered in the treatment of biological rhythm disorders in patients with methamphetamine use disorder. It may also be useful to evaluate these patients in terms of depression and sleep quality.