Impaired autonomic regulation in hyperglycemia and cardiovascular dynamics during autologous blood donation (1072.7)

Abstract

Hyperglycemia has been reported as a risk factor for autonomic dysfunction. However, the changes in autonomic nerve activity that occur in hyperglycemic patients during blood volume reduction are unclear. This study aimed to investigate the impact of hyperglycemia (HbA1c 蠅 6.5%) on autonomic nerve activity and cardiovascular dynamics during blood volume reduction (300‐400 mL), by using autologous blood donation as a model of mild blood loss.We compared the impact of hyperglycemia and non‐hyperglycemia on heart rate variability, including circulatory regulation, in 17 patients (mean age 60.9 ± 13.6 years) with no circulatory, respiratory, or cranial nerve disease.During autologous blood donation, none of the patients experienced significant changes in blood pressure or heart rate. In non‐hyperglycemia, the low frequency/high frequency component ratio (LF/HF) significantly increased (p < 0.05) and HF decreased during autologous blood donation. In hyperglycemia, LF/HF and HF responses were lower than in non‐hyperglycemia.These results show that hyperglycemia impaired autonomic regulation during a blood volume reduction of approximately 10% of the circulatory blood volume. This suggests that circulatory failure may be more common in hyperglycemic patients than in non‐hyperglycemic patients during moderate or severe blood volume reduction.