Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

Tobias Schwerd,Neil Shah,Gesche Düker,Sumeet Pandey,Huei-Ting Yang,Elisabeth Jameson,A Muise ,Ramnik J Xavier ,Jonathan Jung,Mads Gyrd‐Hansen ,Nick Platt,Heiko Runz,Helen Chapel,Claire Booth,Sibylle Koletzko,Smita Y Patel ,Satish Keshav,Ruth Bettels,Frances M Platt ,Abdul Elkadri,Subra Kugathasan,Fiona Powrie,Katrin Bagola,J E Wraith ,Marianne Rohrbach,Robin Lachmann ,Thorsten Marquardt,Holm H Uhlig

doi:10.1136/gutjnl-2015-310382

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann–Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

Tobias Schwerd, Neil Shah + Show 26 more

Open Access

https://doi.org/10.1136/gutjnl-2015-310382

Copy DOI

Journal: Gut	Publication Date: Mar 7, 2016
Citations: 136	License type: open-access

Affiliation: University of Oxford, University College London, Great Ormond Street Hospital, University Hospital Bonn, SickKids Foundation, University of Toronto, Hospital for Sick Children, Broad Institute, Massachusetts Institute of Technology, Ludwig Cancer Research, Heidelberg University, Oxford BioMedica (United Kingdom), Ludwig-Maximilians-Universität München, University Hospital Münster, Emory University, University Children's Hospital Zurich, National Hospital for Neurology and Neurosurgery, John Radcliffe Hospital

#Nucleotide-binding Oligomerization Domain-containing Protein 2 #X-linked Inhibitor Of Apoptosis Deficiency + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

ObjectivePatients with Niemann–Pick disease type C1 (NPC1), a lysosomal lipid storage disorder that causes neurodegeneration and liver damage, can present with IBD, but neither the significance nor the functional mechanism...

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Similar Papers

Paper Title

Journal

Date

Author

View more papers

More From: Gut

Paper Title

Journal

Date

Author

View more papers

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.