Abstract
Background Human rhinovirus is most prominently associated with asthma exacerbations in humans. The U-BIOPRED project of the Innovative Medicine Initiative (IMI) aims to define biomarkers of asthma exacerbations. Within this context, this study aimed to establish a mouse model of asthma exacerbations induced by viral respiratory infection on the background of chronic allergic airway inflammation.
Highlights
Impaired anti-viral immune response to human rhinovirus 1B infection in chronic allergic airway inflammation does not manifest in asthma exacerbation
Human rhinovirus is most prominently associated with asthma exacerbations in humans
Additional rhinovirus infection did not result in an exacerbation phenotype regarding airway hyperresponsiveness (AHR), Bronchoalveolar lavage (BAL) inflammatory cell counts, draining lymph node cell counts and ex vivo proliferative response
Summary
Human rhinovirus is most prominently associated with asthma exacerbations in humans. The U-BIOPRED project of the Innovative Medicine Initiative (IMI) aims to define biomarkers of asthma exacerbations. Impaired anti-viral immune response to human rhinovirus 1B infection in chronic allergic airway inflammation does not manifest in asthma exacerbation Background Human rhinovirus is most prominently associated with asthma exacerbations in humans. The U-BIOPRED project of the Innovative Medicine Initiative (IMI) aims to define biomarkers of asthma exacerbations.
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