Abstract
BackgroundWNT1-inducible signaling pathway protein 1 (WISP1) is a member of CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression is associated with carcinogenesis. In the current study, we focused on examining WISP1 single nucleotide polymorphisms (SNPs) to elucidate hepatocellular carcinoma (HCC) clinicopathologic characteristics.Methodology/Principal findingsThe WISP1 SNPs rs2977530, rs2977537, rs2929973, rs2929970, rs62514004, and rs16893344 were analyzed by real-time polymerase chain reaction in 332 patients with HCC and 664 cancer-free controls.ResultsThe patients with higher frequencies of WISP1 rs62514004 (AG + GG) and rs16893344 (CT + TT) variants revealed a lower risk to reach a later clinical stage compared with their wild-type carriers. Furthermore, individuals who carried WISP1 rs62514004 and rs16893344 haplotype G-T showed a greater synergistic effect combined with alcohol drinking on HCC development (AOR = 26.590, 95% CI = 9.780–72.295).ConclusionsOur results demonstrated that the HCC patients with WISP1 SNPs are associated with HCC development, and WISP1 SNPs may serve as markers or therapeutic targets for HCC.
Highlights
Hepatocellular carcinoma (HCC) is a deadly cancer; it ranks the second leading cause of male cancer deaths in developing countries and the third most common cause of cancer mortality worldwide [1, 2]
Individuals who carried WNT1-inducible signaling pathway protein 1 (WISP1) rs62514004 and rs16893344 haplotype G-T showed a greater synergistic effect combined with alcohol drinking on hepatocellular carcinoma (HCC) development (AOR = 26.590, 95% confidence interval (CI) = 9.780–72.295)
Our results demonstrated that the HCC patients with WISP1 single nucleotide polymorphisms (SNPs) are associated with HCC development, and WISP1 SNPs may serve as markers or therapeutic targets for HCC
Summary
WNT1-inducible signaling pathway protein 1 (WISP1) is a member of CCN protein family and a downstream target of β-catenin. Aberrant WISP1 expression is associated with carcinogenesis. We focused on examining WISP1 single nucleotide polymorphisms (SNPs) to elucidate hepatocellular carcinoma (HCC) clinicopathologic characteristics. The WISP1 SNPs rs2977530, rs2977537, rs2929973, rs2929970, rs62514004, and rs16893344 were analyzed by real-time polymerase chain reaction in 332 patients with HCC and 664 cancer-free controls
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