Abstract

Parkinson's disease (PD) is a neurological disorder that affects both motor and cognitive functioning. This study aimed to examine the impact of motor phenotype on cognitive function 1 year after subthalamic-nucleus deep brain stimulation (STN-DBS). The prospectively collected data of 37 patients with PD were retrospectively analyzed. The patients were divided into two group according to their motor phenotype: the postural instability and gait disturbance (PIGD) group comprised 16 patients, and the tremor-dominant (TD) group comprised 21 patients. The clinical characteristics and cognitive functions of all patients were examined at baseline and at the 1-year follow-up after STN-DBS. The data showed that STN-DBS significantly improved motor functions (P < 0.05). A repeated-measures analysis of variance indicated a considerable group × time interaction impact on the memory quotient score (P < 0.001) and Tmin (P=0.033). A distinct relationship between the neuropsychological spectrum and motor phenotype of PD patients was observed at the 1-year follow-up after STN-DBS, with worse cognitive outcomes in patients with the PIGD phenotype. Geriatr Gerontol Int 2023; 23: 85-90.

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