Abstract
There is growing evidence supports the regulatory role of the immune system in neuronal function and mental health. Many studies have demonstrated the impact of the immune system in neurodegenerative disorders. There are beneficial therapeutic effects of targeting the immune system in the management of these disorders. However, there are gaps in the available knowledge and many steps are needed to move forward. Sensory contact model (SCM) is an experimental social behavior model which allows the formation of different psychopathological conditions which are originated between male mice by the repeated agonistic interactions; resemble those in human. SCM has been developed to investigate aggression and submission behaviors. It gives the chance to study the pharmacological actions of novel psychoactive drugs. The current study aims to review the possible relations between the immune system and social behavior; using the SCM as an experimental model of aggression and depression. To encourage the production of novel psychoactive drugs target the immune system and inflammatory pathways.
Highlights
The immune system The immune system is a complex array of organs, cells, and soluble factors that constitute a defense mechanism aiming at the preservation of integrity being charged with the ability to identify self and nonself 1
The outcomes of the functional immune system are in most times desirable, as in termination of infection, acquiring resistance against further infection and identifying new antigens such as those expressed by newly arising tumors
Stress or trauma exposure is associated with dysregulation of the autonomic and neuroendocrine systems; these precipitate the release of cytokines which increase symptoms severity through effects on brain circuits critical for the regulation of fear and anxiety. These effects of inflammation on neurotransmitters and neurocircuits are further extended in the review by Brundin et al (2017) 118 who reported an association between inflammatory activation and suicidal behavior reported through psychiatric disorders
Summary
The immune system The immune system is a complex array of organs, cells, and soluble factors that constitute a defense mechanism aiming at the preservation of integrity being charged with the ability to identify self and nonself 1. Central organs (Primary lymphoid tissues): These are organs that provide the microenvironments that support the initial development of immune cells and their priming by expressing their first antigenic receptors during the process of tolerance and attaining phenotypic and functional maturity. Its result is the production of activated T lymphocytes which enter the circulation and migrate to the site of antigenic stimulation 12, 13 These cells can split the antigen into smaller peptides display them on their surface MHC molecules to form the required ligands with T lymphocyte receptors 14. All blood cell types originate from several multipotential hematopoietic stem cells that undergo processes of proliferation and maturation in the bone marrow under the influence of cytokines 20 They include granulocyte, macrophage, and granulocyte/macrophage colony-stimulating factor (G, M, and GM-CSF, respectively); erythropoietin and thrombopoietin. A combination of these two concepts results in five different specific styles of handling interpersonal conflict 38, 42: 1. Integrating: Focuses high concern for self and others
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
