Impact of World War 1 on placenta weight, birth weight and other anthropometric parameters of neonatal health

Abstract

BackgroundWars do not only affect combatant countries, populations in neutral zones can be afflicted by circumjacent conflicts as well, posing a great health burden on mothers and newborns. As neonatal health remains an ongoing cause for concern, identifying determinants that impede fetal growth is crucial. Under this pretext, the study aimed to analyze the impact of World War 1 in the neutral city of Basel on neonatal health by assessing changes in anthropometric parameters. MethodsA retrospective analysis of yearly cross sections of term births in the maternity hospital of Basel from 1912 to 1923 was conducted (n = 3718). We tested adjusted anthropometry for time trends in comparison to a pre-war baseline, including birth weight, placenta weight, birth length, ponderal index and gestational age. Interrelations of placenta weights and birth weights were examined separately through birth weight to placenta weight (BW/PW) ratios and residuals of placenta weight to birth weight regressions. ResultsBirth weights, placenta weights and residuals were at their lowest in 1918/19, a trend not reflected in BW/PW ratios. Birth lengths remained low while ponderal indexes declined during the entire period of war, gestational age remained rather stable. Discussion1918/19 were the pinnacle years for the population of Basel, who were suffering from general detrimental economic conditions, a food supply crisis and an outbreak of the Spanish Flu. These adverse circumstances coincided with low birth and placenta weights, residuals depicting the correlation of birth weights to placental weights more closely than bw/pw ratios.