Abstract

ScopeObesity causes DNA damage, which is causally related to several disorders including cancer, infertility, and cognitive dysfunctions. The aim of this study is to investigate whether weight loss improves the integrity of the genetic material.Methods and ResultsOverweight mice are fed ad libitum either with a Western diet (WD), with a 40% caloric restricted WD, or with a high carbohydrate low protein (HCLP) diet. Caloric restriction and also the HCLP diet lead to ca. 30% weight loss, which is paralleled by decreased DNA damage (“comet” formation) and oxidative damage of purines in inner organs, additionally the activity of nucleotide excision repair increased. The effects are more pronounced in animals that have received the HCLP chow. Results of biochemical analyses indicate that the reduction of DNA damage is associated with a decrease of pro‐inflammatory cytokines and lower insulin levels.ConclusionThe study indicates that weight loss may prevent obesity‐associated adverse health effects due to reduction of overall DNA damage.

Highlights

  • Scope: Obesity causes DNA damage, which is causally related to several disorders including cancer, infertility, and cognitive dysfunctions

  • Caloric restriction and the HCLP diet lead to ca. 30% weight loss, which is paralleled by decreased DNA damage (“comet” formation) and oxidative damage of purines in inner organs, the activity of nucleotide excision repair increased

  • The weight loss phase started at week 15, when the animals were switched to either a 40%-R-Western diet (WD) or an AL-HCLP diet (Figure 1A)

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Summary

Objectives

The aim of this study is to investigate whether weight loss improves the integrity of the genetic material. The aim of the present study was to investigate if weight reduction improves the integrity of the genetic material. The aim of this study was to investigate whether weight loss improves the integrity of the DNA, which plays an important role in the etiology of various diseases that are associated with increased body mass

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