Impact of Vitamin D Elements in Insulin Sensitivity in Type 2 Diabetes Mellitus (DM2)

Abstract

Numerous non-skeletal diseases have been reported to be associated with vitamin D status including type2diabetes mellitus (T2DM). Different studies provide evidence that vitamin D status as well as other elementssuch as vitamin D binding protein (DBP) and vitamin D receptor (VDR) may play substantial role in glucosetolerance. Present study was designed to investigate the role of vitamin D status and their elements ininsulin resistance or sensitivity in T2DM patients Current study includes 84 participants of both gender(56 patients and 28 as control). Clinical samples were collected from clinically proved DM2 patients.Serum levels of insulin, FBS, VD, VDR, and DBP were measured of each subjects. Using of HomeostasisModel Assessment Insulin resistance (HOMA-IR), T2DM patients were sub grouped to insulin resistance(IR) and insulin sensitivity (IS) groups. Relations among studied factors, FBS showed significant positiveand negative relation with HOMA-IR and VD3 respectively, furthermore HOMA-IR revealed significantpositive relation with DBP and VDR. Also, DBP revealed significant positive relation with each of VDRand HOMA-IR. On the other hand, VD3 levels showed significant and non-significant elevation in IS groupcompared to C and IR group respectively, while DBP revealed significant and non-significant dropping in ISgroup compared to C and IR groups respectively. Levels of VDR in IS group showed significant droppingcompared to C and IR groups respectively. Our study concludes that VD3 alone or with its elements playsubstantial role in regulation of blood sugar levels particularly related to insulin sensitivity