Impact of vitamin D deficiency on prognosis for patients in geriatric intensive care unit

Abstract

Objective To investigate the prevalence of vitamin D deficiency in patients in geriatric intensive care unit and the impact of vitamin D deficiency on the prognosis. Methods 213 hospitalized patients admitted into geriatric intensive care unit of Xinhua Hospital, Shanghai from June 2012 to December 2013 were included in the historical cohort study. Serum 25-hydroxyvitamin D [25(OH)D]was examined in all the subjects. Main laboratory findings, the incidence of multiple organ dysfunction syndrome (MODS), Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ) score and mortality rate of 30-day kept in hospital were compared among patients with different serum 25-hydroxyvitamin D level. Potential risk factors for mortality were analyzed by multivariate logistic regression analysis. Results 25(OH)D deficiency was identified in 82 patients (38.5%), 25(0H)D insufficiency in 90 patients (42.3%), and 25(OH)D sufficiency in 41 patients (19.2%). Compared with 25(0H)D sufficiency group, 25(0H)D deficiency group showed the increased levels of APACHE II score, plasma lactic acid, C reactive protein (CPR), the incidence of MODS and mortality rate (21.65±8.89 vs. 17.05±8.03, 1.89±0.76 mmol/L vs. 1.86±1.03 mmol/L, 101.08±48.23 mg/L vs. 92.48±38.56 mg/L, 42.7% vs. 19.5%, 30.5% vs. 9.8%, all P<0.05). Multiple logistic regression analysis suggested that 25(OH)D deficiency was an independent risk factor for mortality. 25(OH)D levels were negatively correlated with length of stay in geriatric intensive care unit (r=-0.18, P<0.05). Conclusions Vitamin D deficiency is highly prevalent among patients admitted into geriatric intensive care unit. Vitamin D deficiency is associated with disease severity and may be an independent risk factor for mortality. Key words: Vitamin D deficiency; Intensive care unit; Prognosis