Abstract
BackgroundVisual processing network is one of the functional networks which have been reliably identified to consistently exist in human resting brains. In our work, we focused on this network and investigated the intrinsic properties of low frequency (0.01–0.08 Hz) fluctuations (LFFs) during changes of visual stimuli. There were two main questions to be discussed in this study: intrinsic properties of LFFs regarding (1) interactions between visual stimuli and resting-state; (2) impact of repetition rate of visual stimuli.Methodology/Principal FindingsWe analyzed scanning sessions that contained rest and visual stimuli in various repetition rates with a novel method. The method included three numerical approaches involving ICA (Independent Component Analyses), fALFF (fractional Amplitude of Low Frequency Fluctuation), and Coherence, to respectively investigate the modulations of visual network pattern, low frequency fluctuation power, and interregional functional connectivity during changes of visual stimuli. We discovered when resting-state was replaced by visual stimuli, more areas were involved in visual processing, and both stronger low frequency fluctuations and higher interregional functional connectivity occurred in visual network. With changes of visual repetition rate, the number of areas which were involved in visual processing, low frequency fluctuation power, and interregional functional connectivity in this network were also modulated.Conclusions/SignificanceTo combine the results of prior literatures and our discoveries, intrinsic properties of LFFs in visual network are altered not only by modulations of endogenous factors (eye-open or eye-closed condition; alcohol administration) and disordered behaviors (early blind), but also exogenous sensory stimuli (visual stimuli with various repetition rates). It demonstrates that the intrinsic properties of LFFs are valuable to represent physiological states of human brains.
Highlights
Visual network is one of the functional networks which have been reliably identified to consistently exist in human resting brains [1,2]
By comparing Fig. 1(b)/(b)9 with Fig. 1(a)/(a)9, more areas of visual network were involved in visual processing when restingstate was replaced by visual stimuli
With increasing visual repetition rate, more areas of visual network were involved in visual processing, as Fig. 1(b)/(b)9–(d)/(d)9 shows
Summary
Visual network is one of the functional networks which have been reliably identified to consistently exist in human resting brains [1,2]. There have been many studies demonstrating the correlations between endogenous factor/behavior modulations and intrinsic properties of LFFs in this network. Visual network is altered by modulations of both endogenous factors (EO, EC, and alcohol administration) and disordered behaviors (early blind). Visual processing network is one of the functional networks which have been reliably identified to consistently exist in human resting brains. We focused on this network and investigated the intrinsic properties of low frequency (0.01–0.08 Hz) fluctuations (LFFs) during changes of visual stimuli. There were two main questions to be discussed in this study: intrinsic properties of LFFs regarding (1) interactions between visual stimuli and resting-state; (2) impact of repetition rate of visual stimuli
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