Abstract
Dendritic cells play key role during tumorigenesis and immune response to it. They are able to uptake and present antigens to T cells, resulting in specific T cell mediated immune response. Furthermore, interaction between dendritic cells and other types of immune cells may boost cell-mediated and humoral immune response to cancer. Contrary to that, numerous tumor-derived factors may attract dendritic cells to neoplastic sites, causing impairment of their maturation, differentiation, and functional activity, resulting in deficiency of anti-tumor immune response or dendritic cell-mediated tolerance. Various factors within tumor microenvironment may either stimulate or inhibit dendritic cells and therefore need to be determined for improving efficacy of biotherapy utilizing dendritic cells. Meanwhile, recovery of dendritic cells functions in cancer patients remains one of primary aims for cancer immunotherapy. This review outlines main types of tumor-derived factors and their impact on dendritic cells in cancer.
Highlights
R. et al Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
L. et al Lung cancer-derived bombesin-like peptides down-regulate the generation and function of human dendritic cells
Ding G., Zhou L., Qian Y. et al Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-2123p
Summary
Дендритные клетки играют уникальную и разнообразную роль в процессе онкогенеза и развития иммунного ответа на присутствие в организме опухолевых клеток. С другой стороны, ряд выделяемых опухолью факторов способен привлекать дендритные клетки в очаг неоплазии, нарушать их созревание, дифференцировку и функциональную активность, тем самым приводя к дефициту противоопухолевого иммунного ответа или опосредованной дендритными клетками толерантности организма к опухоли. Dendritic cells play key role during tumorigenesis and immune response to it. They are able to uptake and present antigens to T cells, resulting in specific T cell mediated immune response. Interaction between dendritic cells and other types of immune cells may boost cell-mediated and humoral immune response to cancer. This review outlines main types of tumor-derived factors and their impact on dendritic cells in cancer. Дендритные клетки (ДК) играют ключевую роль в инициировании и поддержании противоопухолевого иммунитета, при этом объединяя усилия врожденного и приобретенного звеньев иммунной системы
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