Abstract
Transition metal ions are essential micronutrients for all living organisms and play an important role in bone metabolism. In the present study, we investigated the impact of transition metal ions (Cu, Co, Mn, Fe) on the structure and bioactivity of bioactive glasses. The emphasis was laid on understanding their influence on the chemical dissolution behavior of glasses and its impact on their vitro bioactivity, osteoblast proliferation and oxidative stress levels. The structure of glasses was studied by using molecular EXAFS in combination with Raman spectroscopy. The apatite-forming ability of glasses has been investigated by X-ray diffraction, infrared spectroscopy after immersion of glass powders in simulated body fluid (SBF) for time durations varying between 1 and 7 days. A significant effect on the bioactivity was observed with addition of transition metal ions. The cellular responses were observed in vitro on glass powders using human osteosarcoma MG63 cell line. The dose-dependent cytoprotective effect of glasses with respect to the concentration of transition metal ions (Cu, Co, Mn, Fe) released from the glasses is also discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
