Abstract
BackgroundThis study aimed to investigate whether age at complete repair of tetralogy of Fallot (TOF) impacts postoperative morbidity and length of hospital stay in infants less than 365 days of age.MethodsThe United States Nationwide Inpatient Sample was searched for infants 0–365 days of age that underwent complete repair of TOF between 2005 and 2011. Patients were categorized based on age at time of repair: 0–30 days; 31–90 days; 91–180 days; > 180 days.ResultsA total of 1112 infants were included in the study. Multivariate analysis showed the risk of postoperative complications was 40% lower in infants ≥91 days old at the time of repair as compared to those ≤30 days old. In addition, children > 30 days old at the time of repair had a significantly shorter length of hospital stay than those aged ≤30 days. In the subgroup with elective repair, older age was associated with a shorter length of hospital stay as compared to those ≤30 days old at repair, while association between age at complete repair of TOF and postoperative complication was not significant among the groups after adjusting for confounders.ConclusionsIn children < 1 year old, postoperative complications and length of hospital stay are affected by the timing of complete repair of TOF.
Highlights
This study aimed to investigate whether age at complete repair of tetralogy of Fallot (TOF) impacts postoperative morbidity and length of hospital stay in infants less than 365 days of age
The Nationwide Inpatient Sample (NIS) was developed as part of United States Healthcare Cost and Utilization Project (HCUP), which is sponsored by the Agency for Healthcare Research and Quality
There were 55,906,462 hospitalizations recorded during the period from 2005 to 2011 in the HCUP-NIS database
Summary
This study aimed to investigate whether age at complete repair of tetralogy of Fallot (TOF) impacts postoperative morbidity and length of hospital stay in infants less than 365 days of age. Tetralogy of Fallot (TOF) accounts for approximately 5 to 7% of all congenital cardiac conditions [1, 2]. As the most common form of cyanotic congenital heart disease, the prevalence of TOF is approximately 3.9 cases per 10,000 live births [1, 2]. The traditional method for asymptomatic infants has been to wait until symptoms develop or the children are older to decrease the morbidity and mortality associated with operating on infants, and surgery at a younger age has been associated with an increased need for transannular patching at a later date [6]. For infants who are cyanotic, the decision revolves around a palliative shunt procedure and complete repair at a later date or initial complete repair [7, 8]
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