Abstract
In modern society, more and more people suffer from circadian disruption, which in turn affects health. But until now, there are no widely accepted therapies for circadian disorders. Rhythmic feeding behavior is one of the most potent non-photic zeitgebers, thus it has been suggested that it was important to eat during specific periods of time (time-restricted feeding, TRF) so that feeding is aligned with environmental cues under normal light/dark conditions. Here, we challenged mice with a 6 h advanced shift, combined with various approaches to TRF, and found that food restricted to the second half of the nights after the shift facilitated adaptation. This coincided with improved resilience to sepsis. These results raise the possibility of reducing the adverse responses to jet lag by subsequent timing of food intake.
Highlights
Despite an increasing awareness of the hazards of circadian disruption, modern lifestyle is subject to frequent desynchronization due to shift working, artificial light, and transmeridian air flight
While the molecular clock may be adjusted by small molecules that target clock proteins (Cho et al, 2012; Solt et al, 2012; Wallach and Kramer, 2015), we have found that inhibiting circadian rhythms may mitigate circadian disorders (Yang et al, 2019, 2020)
Lights-on was at 08:00 h, defined as zeitgeber time 0 (ZT0), and lights off at 20:00 h defined as ZT12
Summary
Despite an increasing awareness of the hazards of circadian disruption, modern lifestyle is subject to frequent desynchronization due to shift working, artificial light, and transmeridian air flight. Studies in rodents suggest the benefits of eating during specific periods of time (timerestricted feeding, TRF) so that feeding is aligned with light cues. If food is available only at night, during the active phase in mice, it can prevent the metabolic syndrome induced by a high-fat diet (Hatori et al, 2012), and even reverse pre-existing obesity and impaired glucose tolerance (Chaix et al, 2014). These beneficial effects are lost on reversion to more temporally disrupted ad libitum feeding
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